Novel Curcumin Intravenous Injection System: Preparation, Characterization, Improved Bioavailability and Safety In Vitro and In Vivo

Curcumin (CUR), a naturally bioactive component in the Curcuma longa have a wide range of biological and pharmacological actions. However, the poor water solubility with poor bioavailability limits its application. The aim of this study was to develop a novel CUR intravenous injection to improve CUR absorption and enhance drug therapy effect. The physical characteristics of CUR intravenous injection such as particle size, zeta potential and drug content were all investigated in detail. This formulation did not cause hemolysis and intravenous irritation. Pharmacokinetics results showed the Cmax and area under the curve (AUC) of CUR after intravenous administration was than those of oral administration. This study demonstrated the CUR intravenous injection may be a promising delivery system of CUR to improve bioavailability and clinical therapeutic effect in the future.